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Author Topic: Serious (bio)medical height increase research projects  (Read 183950 times)
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HaraldO
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« Reply #200 on: June 12, 2017, 09:27:43 PM »

Hello,
a nice piece of work concerning bone formation and function.
Best wishes
Harald

Quote:
"Researchers discover mechanism that controls bone formation, function
Date:
    May 30, 2017
Source:
    University of Arkansas, Fayetteville
Summary:
    A mechanism that controls the formation and function of plate-like nanocrystals that play a critical role in bone composition has now been discovered by researchers.

An international, multidisciplinary research team, including an engineering professor at the University of Arkansas, has discovered a mechanism that controls the formation and function of plate-like nanocrystals that play a critical role in bone composition.

The researchers' discovery, published in the May 2017 issue of Biomaterials, advances the field of tissue engineering and could lead to the creation of a synthetically produced biomaterial to replace bones.

Arun Nair, assistant professor of mechanical engineering, contributed to the project by generating computational models at the nanometer scale. A nanometer is about the width of two silicon atoms. The simulations were performed at the U of A's Arkansas High Performance Computing Center. To predict the mechanical properties, Nair relied on density functional theory, a quantum mechanical modeling method used to understand the structure of atoms, molecules and other biological processes.

"This research suggests, for the first time, that a chemical substitute, in absence of protein or other organic substances, affects the crystallite morphology of bone mineral," Nair said. "These are nanometer-sized crystallites, but still, the finding provides a much better understanding of the processes that control size and shape of particles that make up bone."

Bone is composed of protein collagen and mineral in the form of plate-like nanocrystals. Previous research has shown that the mineral crystallites play a critical role in proper bone function and physiology. Their nanometer size renders them nearly flawless, which contributes to bone strength. Though researchers have known that nanocrystal size and morphology are critical to the proper mechanical and physiological functioning of bone, the mechanism that controls these properties has been unclear.

Mimicking biochemical processes, the researchers synthesized apatite nanocrystals with carbonate. Apatite is a group of phosphate minerals. The nanocrystals exhibited morphologies similar to those seen in natural bone mineral. Nair's atomistic models of the apatite nanocrystals helped the research team gain a better understanding of the mechanical properties of apatite crystals.

Story Source:

Materials provided by University of Arkansas, Fayetteville."
( https://www.sciencedaily.com/releases/2017/05/170530082337.htm )
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10Inches
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« Reply #201 on: September 03, 2017, 08:05:51 AM »

I think i'ts pretty obvious that in nearest future scientists will find out how to reverse your bone fused growth regions back to epiphyseal plates and perform a natural bone-growth process.
And I don't think its gonna be in 30 years, because speed of science research and grows every day, computers become more and more powerful.  I think such technology will be available in 15 years maximum.
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HaraldO
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« Reply #202 on: September 04, 2017, 04:12:20 PM »

Dear 10Inches,
I agree, that the technology would be available to develop a safe and effective height increase therapy. But unfortunately currently no research groups are working towards that goal. So we (short statured people) must make clear, that we want such a therapy ... and in the best case we could attract some investors or donators in order to fund such innovative height increase research. If we donīt support the development of a safe and effective biomedical height increase therapy, it will take much more time ...
Best wishes
Harald
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HaraldO
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« Reply #203 on: September 06, 2017, 03:59:32 PM »

Hello,
below you will find some information concerning a combination of gene and stem cell therapy for new bone growth. This may be a good idea for accelerating the recovery time after traditional limb lengthening or could maybe become a part of a separate strategy for increasing bone length.
Best regards
Harald


Soon, Broken Bones Could be Fixed Using Gene Therapy and Microbubbles

In Brief
Researchers healed bone fractures by attracting stem cells to the area and injecting a mix of microbubbles and DNA encoding a bone protein at the break. This method could replace bone grafting for nonhealing fractures.

Better Than Bone Grafts

Fixing broken limb bones after serious injuries can challenge even the most skilled orthopedic surgeons. Too much bone loss makes regrowth impossible, and even smaller fractures make bone growth problematic if the patient is in poor health or at an advanced age.

When physicians encounter these kinds of nonhealing fractures, autologous bone grafts are the gold standard for treatment. These bone grafts involve harvesting a segment of healthy bone, typically from the pelvis of the patient, which is then used to ďbridgeĒ the portion of the break that isnít growing new bone adequately. However, bone grafts are not always possible, depending on the patientís health and the extent of the damage from the break.

Some doctors in recent years have started to try something new: incorporating bone morphogenetic proteins (BMPs) into bone implants to enhance healing. This isnít a sure thing, though. Through their traditional administration, BMPs come with significant side effects including bone formation in soft tissues and bone resorption.

These side effects might have occurred because BMPs were administered in large doses, so researchers came up with a new strategy: use gene therapy to deliver not the protein itself, but the underlying gene instead. This way the cells will get BMP at physiological levels solely at the site of the injury.
Delivering Gene Therapy

However, getting gene therapies into the right cells isnít always easy. The genes are typically delivered using viral vectors, and these come with their own safety concerns. The researchers in this case used a relatively new delivery mechanism instead: sonoporation.

In sonoporation, an ultrasound is used to cause gas-filled microbubbles with lipid shells to oscillate and create tiny, easily repaired holes in cells. These tiny holes allow DNA for gene therapy to enter into the right place without affecting other areas. The next step was ensuring that the gene therapy targeted the correct cells. The team targeted a special form of stem cells that can become bone cells and produce BMPs proficiently.

The researchers trialled their new strategy in broken pig shinbones and found that the technique healed fractures after a single dose. They first inserted collagen scaffolds, because they attract the stem cells, and then waited for two weeks to allow the scaffolds to recruit sufficient numbers of stem cells.

Next, they injected a mix of microbubbles and BMP-encoding DNA at the fracture site, and applied an ultrasound pulse. The team then waited for eight weeks after the single instance of the gene therapy. The experimental fractures were healed, while the control animalsí fractures were not.

This innovative therapy could improve the recovery of millions of people around the world. While human trials must be conducted before we know whether hospitals should adopt the procedure, many of its components have shown enough promise for scientists to utilize them in similar bone-healing experiments: One fracture-fixing strategy incorporates a specific form of BPM, and another therapy uses stem cells to revitalize bone growth.

(Source: https://futurism.com/soon-broken-bones-could-be-fixed-using-gene-therapy-and-microbubbles/ )
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